Positive COVID Test? Sign up for a clinical trial.
A number of currently available drugs that may reduce the impact of COVID-19 are being evaluated. To find a clinical trial that is right for you, use this Clinical Trial Finder.
Project Topics
Fluvoxamine for COVID
Fluvoxamine is an existing medication that has shown great promise for treatment of COVID-19 infection. It is an SSRI (selective serotonin reuptake inhibitor) antidepressant that is commonly prescribed for obsessive-compulsive disorder.
Fluvoxamine’s ability to fight inflammation and block activation of platelets likely reduce the incidence of sepsis and blood clots that are common features of severe COVID-19 infection.
Results from a small randomized, placebo-controlled study of fluvoxamine was reported by researchers from Washington University. In 152 adult outpatients with symptomatic COVID-19, none treated with fluvoxamine had worsening symptoms but 8.3% of the control group got worse.
Additional real-world experience supported the use of fluvoxamine. In an outbreak of COVID-19 at the Golden Gates Field Racetrack, physicians offered fluvoxamine to the 113 individuals testing positive. In total, 65 persons opted for fluvoxamine, and 48 opted for observation alone. None of the patients selecting fluvoxamine were hospitalized and all recovered, while six of those not taking the medication (or 12.5%) were hospitalized, many had lingering symptoms, and one died.
The Together Trial is a randomized, controlled clinical trial conducted in Brazil that recently reported on the use of fluvoxamine for treatment of COVID-19. Of 1497 people with high-risk of serious COVID outcomes, 11% of those who received fluvoxamine required extended emergency room visits or hospitalization compared to 16% of those who received a placebo. For individuals who took most of the fluvoxamine doses, the death rate was reduced 91%.
Some physicians may offer existing medications like fluvoxamine off-label to COVID-19 patients. The University of Minnesota COVID-OUT clinical trial and the ACTIV-6 trial are both evaluating fluvoxamine for COVID treatment in the United States.
Take Action
If you recently tested positive for COVID, you can sign up for a clinical trial or use our clinical trial finder:
- COVID OUT – University of Minnesota trial evaluating fluvoxamine, ivermectin, metformin.
- ACTIV-6 – NIH trial evaluating fluvoxamine, fluticasone, ivermectin.
Additional Resources
Fluvoxamine
- Encyla review
- COVID-19 Early Early Treatment Fund review of data
- Lenze EJ, Mattar C, Zorumski CF, et al. (2021). Fluvoxamine vs Placebo and Clinical Deterioration in Outpatients With Symptomatic COVID-19: A Randomized Clinical Trial. JAMA. 2020 Dec 8;324(22):2292-2300. (free full text)
- Reis G, Silva E, Silva D, et al. (2021). Effect of early treatment with fluvoxamine on risk of emergency care and hospitalisation among patients with COVID-19: The TOGETHER Randomized Platform Clinical Trial. Lancet Oct 27, 2021. (free full text)
- Seftel D, Boulware DR. (2021). Prospective cohort of fluvoxamine for early treatment of coronavirus disease 19. OFID 8(2):1-3. (free full text)
Human Health News
Fluvoxamine decreased hospitalization for COVID positive people
A new scientific publication reported that the drug fluvoxamine reduced hospitalization for high-risk COVID-positive adults. Fluvoxamine is an inexpensive medication commonly used to treat depression
Ivermectin studied in University of Minnesota COVID treatment trial
Despite warnings from medical professionals, the social media buzz about ivermectin’s ability to cure COVID has continued. The result has been a tremendous increase in
Hormone restoration therapy for a neutered male dog
Research on spaying and neutering has increasingly provided evidence of potential negative effects on lifelong health in dogs. Hormone-sparing sterilization is a way to preserve
Fluvoxamine decreased hospitalization for COVID positive people
A new scientific publication reported that the drug fluvoxamine reduced hospitalization for high-risk COVID-positive adults. Fluvoxamine is an inexpensive medication commonly used to treat depression
Ivermectin studied in University of Minnesota COVID treatment trial
Despite warnings from medical professionals, the social media buzz about ivermectin’s ability to cure COVID has continued. The result has been a tremendous increase in
Hormone restoration therapy for a neutered male dog
Research on spaying and neutering has increasingly provided evidence of potential negative effects on lifelong health in dogs. Hormone-sparing sterilization is a way to preserve
Major story questions spay-neuter for dogs
Whether dogs should automatically undergo spay or neuter procedures is the topic of a story by Alexandra Ellerbeck in the Washington Post. She reports that
