Testosterone, Cognition & Aging Men

Evaluating the effects of testosterone and DHA on memory

Summary: An ongoing clinical trial in Australia will lead to better understanding of the influence of testosterone and DHA on Alzheimer’s disease  

The Parsemus Foundation provided early support for a randomized controlled prospective trial on the impact of testosterone or DHA (a type of omega-3 fat found in fish oil) versus placebo on the onset of amyloid plaque associated with Alzheimer’s disease in men with memory complaints. The study is being conducted at the McCusker Alzheimer’s Research Foundation in Western Australia. Based on the results of a smaller non-placebo trial, the researchers led by Dr. Ralph Martins are optimistic that one or both treatments may slow the development of amyloid plaque and cognitive decline.

The trial has been screening men by completing a positron emission tomography (PET) amyloid scan prior to selection for the trial. In addition to the treatment arms, blood tests and retinal images from all participants will help to develop early diagnostic tests for Alzheimer’s disease.

Take action

Additional funding is required to complete this clinical study. Contact info@parsemus.org if you are interested in supporting this important work.

More info

For general information, research trials, and prevention information regarding Alzheimer’s disease, see: Alzheimer’s Association, Alzheimer’s Research and Prevention Foundation, list of Alzheimer’s Research Centers and Organizations.

Asih PR, Tegg ML, Sohrabi H, Carruthers M, Gandy SE, Saad F, Verdile G, Ittner LM, Martins RN. (2017). Multiple mechanisms linking type 2 diabetes and Alzheimer’s disease: Testosterone as a modifier. J Alzheimers Dis. 59(2): 445–466. (Free full text).

Martins RN, Villemagne V, Sohrabi HR, et al. (2018). Alzheimer’s disease: A journey from amyloid peptides and oxidative stress, to biomarker technologies and disease prevention strategies-Gains from AIBL and DIAN cohort studies. J Alzheimers Dis. 62(3):965-992. (Free full text).

Thomas J, Thomas CJ, Radcliffe J, Itsiopoulos C. (2015). Omega-3 fatty acids in early prevention of inflammatory neurodegenerative disease: A focus on Alzheimer’s disease. Biomed Res Int. 2015:172801. (Free full text).