Shrinking Tumors Nonsurgically

Sleeping dog with visible head tumor

Project Summary

An injection of calcium chloride solution has been shown to reduce the size of tumors in dogs. Other chemical solutions have also been used successfully in canine and human patients. This method can increase the wellbeing of pets suffering with large or painful tumors – without surgery.
  • Mammary tumors and benign masses are common in older dogs and other pets.
  • Large tumors can restrict movement, cause pain, and even rupture (especially when licked or rubbed).
  • Common treatment involves surgery, which is not recommended for many older animals and not practical in some environments.
  • A nonsurgical treatment for tumors would provide an option for pets that cannot undergo surgery or in low-resource or remote settings.
  • Injection of a necrotizing chemical, such as calcium chloride solution, has been shown to reduce the bulk of tumors.
  • More research will help to elucidate differences between chemical solutions and standardize practices.
  • Parsemus Foundation supports the use of low-cost, noninvasive treatments for pets and encourages veterinarians to consider offering these treatments and sharing experiences.

Project Topics

Tumor bulk reduction

Older dogs often get mammary tumors and benign masses. Though benign, these lumps can cause problems if they get very large or start to restrict movement. They can be surgically removed, but this is not an option for many older dogs due to the risk of anesthesia and recovery.

Calcium chloride dihydrate solution, which is used as a testicular injection to shrink the testes for nonsurgical neuter, may be an option for tumor bulk reduction too. The first known report of this use was in 1977 by Koger. Besides allowing veterinarians to offer their clients an anesthesia-free treatment for older dogs, calcium chloride solution has the advantage of being made from readily available ingredients and thus being an option for use in exceedingly low-resource or remote settings. It provides an option for treating animals that otherwise wouldn’t get treated.

Mammary tumor reduction in older dog using injection of calcium chloride

A case study using 0.3-0.5 ml injections of alcohol and 20% calcium chloride in alcohol was successful in reducing the bulk of a mammary mass on the abdomen of an older female dog by 75%. The study was presented in 2011.

Bunny Tumors
Left: Mammary tumor before treatment; Center: Inflammation that occurred after calcium chloride injection, which subsided within 2 weeks; Right: Reduction in size of tumor following treatment.
 

Veterinarians can order the solution from a sterile-filling-capable compounding pharmacy by requesting “20% (w/v) Calcium Chloride Dihydrate, USP in Ethyl Alcohol 190 proof, USP.”

Treatment of lipomas (fatty tumors)

Calcium chloride has been used to reduce the size of lipomas, which are fatty tumors. Albers and Theilen (1985) published a study using 10% calcium chloride injected into the subcutaneous lipomas of 10 dogs. The authors reported that six months later, four tumors had disappeared and 14 were less than 50% of their original size. However, skin necrosis over the tumor developed in three dogs.

A higher concentration of calcium chloride is likely counterproductive. Our experience using 20% calcium chloride in alcohol in a lipoma resulted in complications. By 24-48 hours after the injection, the mass may be shrunk by half, but the skin ruptured, creating a draining wound that had to be treated with antibiotics. Severe complications may result in surgical excision. It may be that the body cannot absorb the lipoma adequately using the 20% calcium chloride, but more research is needed to clarify this issue.

Other nonsurgical injections to treat lipomas have been attempted. A study in 2005 by Rotunda and colleagues evaluated deoxycholate, a bile salt, to treat lipomas in human patients. They reported an average of 75% reduction in tumor size after 2 or more injections, and concluded that this injectable treatment might be useful for small lipomas, but that further research was needed. Steroid injection (triamcinolone acetonide at a dose of 40 mg/mL) was also used to treat lipomas in dogs (Lamagna et al., 2012). Nine of 15 tumors showed a complete regression, with shrinkage in the remaining dogs with only minor complications.

Take Action

While calcium chloride in alcohol and several other chemicals appear to be effective in reducing the size of certain benign tumors, more research will help to quantify results and evaluate options for lipomas.

If you are a veterinarian who offers calcium chloride or other injectable tumor reduction treatments, please sign up for our Veterinary Directory and let us know of your experience. If you are interested in collecting research data on the use of calcium chloride solution for tumor bulk reduction, please contact us.

If you are a pet owner who is looking for nonsurgical tumor reduction options, please check our Veterinary Directory for practitioners who offer this service. Keep in mind that this technique is not yet in widespread use and there may not be any veterinarians nearby who offer it. In that case, you can provide the information on this webpage to your own veterinarian to determine if a nonsurgical injection is a good option to treat tumors on your pet.

  • Albers GW, Theilen GH, 1985. Calcium chloride for treatment of subcutaneous lipomas in dogs. J Am Vet Med Assoc 186(5):492-4. (Abstract)
  • Lamagna B et al., 2012. Canine lipomas treated with steroid injections: Clinical findings. PLoS One. 7(11): e50234. (Free full text).
  • Lissner E, Montilla H, Kutzler M, 2011. Intralesional injection of calcium chloride dihydrate in alcohol for minimally-invasive bulk reduction of a mammary mass. (Poster download)
  • Koger, LM, 1977. Item #451 of the Annual Meeting of the American Society of Animal Science, University of Wisconsin, July 24-27, 1977. (Abstract)
  • Koger, Nov 1977. Calcium Chloride, Practical Necrotizing Agent. J Am Assoc Bovine Pract 12:118–119. (Free full text)
  • Rotunda AM, Ablon G, Kolodney MS, 2005. Lipomas treated with subcutaneous deoxycholate injections. J Am Acad Dermatol 53(6):973-8 (Abstract)

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